Strand-coordinated mutagenesis Topography Examination could not be executed for strand-coordinated mutagenesis as the quantity of fulfilling our constraints was inadequate or this signature was not yet analysed.
We then carried out metagenomic Examination on the same samples to find the existence of reads from pks+ genes. As revealed in Fig. three, the pks+ genes could be detected within the sequencing facts with the samples (possibly cancers or usual) in 19 patients out of thirty, thus validating the presence of your mutational and indel signatures (see also Supplementary Figs. six and 7). Notably, whereas the presence of pks+ genes within the sample indicates the existence of your genotoxic E. coli strands, the mutational signature is the results of generally past exposure, hence it may be amassed in cell genomes in past times devoid of pks+ currently being existing for the time being of sampling.
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